WP 1-3 Gut microbiota and liver metabolism

Impact of gut microbiota and liver metabolism on energy expenditure

Recommendations for a healthy diet include advice on quality, composition and preparation of foods and on daily energy intake. Assessment of the latter is based on predictions of the subject's basal metabolic rate (BMR) and activity level. BMR represents 60-70% of our daily energy budget followed by physical activity, which in non-athletes con­tributes 10-20%. Thus, a valid prediction of BMR as the main energy sink is essential.

Basal metabolic rate, contributing 60-70% of daily energy expenditure, varies significantly between individual subjects. The residual variation remains unexplained after adjusting for age, sex, body weight, body composition, and mass of meta­bolically active organs.

Objective:

Here, we investigate the contribution of gut microbiota and organ-specific metabolic rates to this residual variation.

Coordinating Investigator

Prof. Dr. Martin Klingenspor

Technische Universität München
Lehrstuhl für Molekulare Ernährungsmedizin
ZIEL Institute for Food and Health

Co-investigators

Dr. Thomas Clavel

Technische Universität München
ZIEL Institute for Food and Health

Email: thomas.clavel[at]tum.de

 

Dr. Klaus Neuhaus

Technische Universität München
ZIEL - Institute for Food & Health
Core Facility Mikrobiom/NGS

Tel.:    +49 (0) 8161 71 5549
Email: neuhaus[at]tum.de

Prof. Dr. Dirk Haller

Technische Universität München
ZIEL Institute for Food and Health

Email: dirk.haller[at]tum.de

Prof. Dr. Hans Hauner

Technische Universität München
ZIEL Institute for Food and Health

Email: hans.hauner[at]tum.de

PD Dr. Thomas Skurk

Technische Universität München
ZIEL Institute for Food and Health

Email: thomas.skurk@tum.de

Jun.- Prof. Dr. Jessica Freiherr

Fraunhofer Institut für Verfahrenstechnik
und Verpackung IVV
Analytische Sensorik

Partner

Dr. Timo Schirmer 

GE Global Research